Mass spectrometry (252Cf-PDMS) study of aminoglycoside antibiotics interaction with nucleic acid components
نویسندگان
چکیده
منابع مشابه
study of dna interaction with ethylenediaminetetraacetic acid and sesamol food additives
برهمکنش dnaتیموس گاوی طبیعی (ct-dna) با اتیلن دی آمین تترااستات (edta)در بافرtris-hcl با 8/7 ph ( دراین ph،edta به نمک دی سدیم تبدیل می شود) وسسامول در بافر tris-hcl با4/7 ph مورد بررسی قرار گرفته است. edta و سسامول استفاده فراوانی در تکنولوژی غذایی و صنعت شیمیایی دارند. مدل اتصال dna مربوط بهedta بوسیله اسپکتروفتومتری جذب، دورنگ نمایی حلقوی(cd)، ویسکومتری وژل الکتروفورز بررسی شده است. طیفuv ...
15 صفحه اولInteraction of aminoglycoside antibiotics with phospholipid liposomes studies by microelectrophoresis.
Microelectrophoresis was found to be a rapid method for studying the interaction between aminoglycoside antibiotics and liposomes prepared from acid phospholipids. The ability to cause charge reversal of liposomes prepared from phosphatidyl inositol was ranked in the order neomycin greater than gentamicin greater than tobramycin greater than amikacin greater than kanamycin greater than ribostam...
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We present here a tutorial review on the electrospray mass spectrometry technique and its applications to the study of drug-nucleic acid non-covalent complexes. Particular emphasis has been made on the basic principles of the technique, to allow even the non-specialist to design fit-for-purpose mass spectrometry experiments and interpret the results. Standard applications will be described in d...
متن کاملAminoglycoside Antibiotics
Aminoglycosides are hydrophilic, polycationic, aminecontaining carbohydrates that are usually composed of three to five rings. Most aminoglycosides are either natural products or derivatives of soil actinomycetes. They are often secreted by these actinomycetes as mixtures of closely related compounds. The polycationic aminoglycoside chemical structure results in a binding both to the anionic ou...
متن کاملNucleic Acid Interaction Analysis
The concept of double stranded DNA forming triple helical complexes with a third strand of nucleic acids via so called Hoogsteenhydrogen bonds has been well established for the last 50 years. However, the topic reentered the big stage with recent publications pointing to an existence of these structures in vivo, highlighting their putative role in chromatin organization and transcriptional regu...
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2002
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.0005f1